Place a towel bar (or maybe 2) on back of guest bedroom door. This will keep your guests' towels, facecloths etc., nearby for them and free up the bathroom of "too much stuff."
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A really good thing to do these days is to run extension cords in your guests bedrooms/personal space in order for them to easily charge the vast array of electrical gadgets such as cell phones, digital cameras, laptops, etc.
This is a page about preparing your home for guests. There are many ways that you can prepare ahead of time for having guests stay at your house. Planning ahead will reduce stress and help make your guests more comfortable.