For loose dresser knobs that will not remain tightened, you might consider bow or ribbon ties. This will work best in children's rooms, bedrooms and bathrooms, since the look is rather feminine. I was so frustrated with my bedroom chest of drawers that I took out the hardware and threaded pretty ribbons through the holes. I made bows, and now, whenever I open a drawer, it tightens the bow. No more problem! Just a simple solution to a small frustration.
This is a page about dresser drawers stick after painting. Its not uncommon for drawers to stick after they have been newly painted. Rubbing the sliding edges of the drawers with a bar of soap or paraffin will usual resolve the issue.
This page is about dresser drawers stuck closed. When a chest of drawers do not open, there are a few things you can try to get the drawers to move freely.