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Many things can cause this. Most likely it is a type of fungus. I would try spraying with fungicide once a week. It also could be bugs. Look under all the leaves for life sucking bugs like aphids and stink bugs and check the stalk for vine bores (little bugs that dig into the plant). You can spray off aphids with a quick spray of the hose and use 7 for most other bugs. As for the vine bores I haven't found any thing that works.
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